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Roger Steven Thrall, Ph.D.
Professor of Medicine
Department of Immunology
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Education
- Marquette University and Medical College of
Wisconsin
Milwaukee, WI
Ph.D., 1977
Immunology
- Eastern Connecticut State University
Willimantic, CT
B.A., 1973
Biology
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Positions and Honors
Positions
- Professor - 2005-Present
Department of Immunology, University of Connecticut Health
Center, Farmington, CT
- Professor, Director of Pulmonary Research - 2001-Present
Pulmonary Division, Department of Medicine,
University of Connecticut Health Center, Farmington, CT
- Director of Clinical Research - 1997-Present
Hospital for Special Care, New Britain, CT
- Associate Professor, Director of Pulmonary Research -
1989-2001
Pulmonary Division, Department of Medicine, University of
Connecticut Health Center, Farmington, CT
- Assistant Professor, Director of Pulmonary Research -
1981-1989
Pulmonary Division, University of Connecticut Health Center,
Farmington, CT
- Instructor - 1979-1980
Department of Pathology, University of Connecticut Health
Center, Farmington, CT
- Postdoctoral Fellow, Lung Immunopathology - 1977-1979
Department of Pathology, University of Connecticut Health
Center, Farmington, CT
Honors
- National Institutes of Health Study Sections, Lung Biology and Pathology - 1991-1994
- National Institutes of Health Study Sections, Pathology A - 1989-1991
- National Institutes of Health Research Career Development Award - 1983-1988
- National Institutes of Health New Investigator Award - 1981-1984
- American Lung Association Research Awards - 1981
and 1982
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Selected Peer-Reviewed Publications
Book
Phan, SH, Thrall RS. Volume 80, 1995. "Pulmonary
Fibrosis." Eds. Executive Editor: Claude Lenfant In the
National Institutes of Health Series: Lung Biology in
Health and Disease, Marcel Dekker Inc., New York, New
York
Chapters
RM Bern, MN Levy, BM Koeppen, BA Stanton. 5th Edition,
2004. “Physiology,” Eds.
Section V, Respiratory System, Chapters 25-30, pages
445-535, Mosby, St. Louis, MO
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Peer Reviewed Publications
Thrall RS,
Peterson LB, Linehan J, Abramoff P, Moore VL. 1978. The
effect of immunization on the uptake of intratracheally
administered antigen. Clin Immunol Immunopathol
10:136-147.
Thrall RS, McCormick JR, Jack RM, McReynolds RA, Ward
PA. 1979. Bleomycin-induced pulmonary fibrosis in the
rat: inhibition by indomethacin. Am J Pathol 95:117-128.
Thrall RS, Phan SH, Showell HJ, Williams DJ, O'Flaherty
JT, Ward PA. 1980. Membrane protein alterations in the
Neutrophil in response to chemotactic factors. Mol
Immunol 17:181-190.
Thrall RS, Peterson LB, Braley JF, Linehan JH, Dawson
CA, Moore VL. 1980. Chronic pulmonary inflammation
modulates the fate of proteins administered by the
respiratory tract. J Lab Clin Med 95:343-350.
Thrall RS, Phan SH, McCormick JR, Ward PA. 1981. The
development of bleomycin-induced pulmonary fibrosis in
neutrophils-depleted and complement-depleted rats. Am J
Pathol 105:76-81.
Phan SH, Thrall RS. 1982. The role of soluble factors in
bleomycin-induced pulmonary fibrosis. Am J Pathol
106:156-164.
Thrall RS, Barton RW, D'Amato DA, Sulavik SB. 1982.
Differential cellular analysis of bronchoalveolar lavage
fluid obtained at various stages during the development
of bleomycin-induced pulmonary fibrosis in the rat. Am
Rev Respir Dis 126:488-492.
Thrall RS, Barton RW. 1984. A comparison of lymphocyte
populations in lung tissue and in bronchoalveolar lavage
fluid of rats at various times during the development of
bleomycin-induced pulmonary fibrosis. Am Rev Respir Dis
129:279-283.
Thrall RS, Swendsen CL, Shannon TH, Kennedy CA,
Frederick DS, Grunze MF, Sulavik SB. 1987. Correlation
of changes in pulmonary surfactant phospholipids with
compliance in bleomycin-induced pulmonary fibrosis in
the rat. Am Rev Respir Dis 136:113-118.
Grunze MF, Parkinson D, Sulavik SB, Thrall RS. 1988. The
effect of corticosteroids on lung volume-pressure curves
in bleomycin-induced lung injury in the rat. Exp Lung
Res 14:183-195.
Thrall RS, Cloutier MM, Guernsey L, Swayne E, Gionfriddo
M. 1992. Eprazinone alters lung lavage lipid levels and
transtracheal ion transport. Exp Lung Res 18:409-420.
Volpe BT, Lin W, Thrall RS. 1994. Effect of
intratracheal dexamethasone on oleic acid induced lung
injury in the rat. Chest 106:583-587.
Lin WH, Cramer S, Turcotte J, Thrall RS. 1997. A diether
phosphonolipid surfactant analog, DEPN-8, is resistant
to phospholipase C cleavage. Respiration 64:96-101.
Thrall RS, Vogel SN, Evans R, Shultz LD. 1997. Role of
tumor necrosis factor-alpha in the spontaneous
development of pulmonary fibrosis in viable motheaten
mutant mice. Am J Pathol 151:1303-1310.
Pohl R Thrall RS, Rogers RA, Kramer PA. 1999. Confocal
imaging of peripheral regions of intact rat lungs
following intratracheal administration of
6-carboxyfluorescein, FITC-insulin, and FITC-dextran.
Pharm Res 16:327-332.
Yiamouyiannis CA, Schramm CM, Puddington L, Stengel P,
Baradaran-Hosseini E, Wolyniec WW, Whiteley HE, Thrall
RS. 1999. Shifts in lung lymphocyte profiles correlate
with the sequential development of acute allergic and
chronic tolerant stages in a murine asthma model. Am J
Pathol 154:1911-1921.
Schramm CM, Puddington L, Yiamouyiannis CA, Lingenheld
EG, Whiteley HE, Wolyniec WW, Noonan TC, Thrall RS.
2000. Proinflammatory roles of TCR and TCR
lymphocytes in a murine model of asthma. Am J Respir
Cell Mol Bio 22:218-225.
Tandon R, Sha’afi RI, Thrall RS. 2000. Neutrophil
B2-integrin upregulation is blocked by a p38 MAP kinase
inhibitor. Biochem Biophy Res Comm 270:858-862.
Wu CA, Puddington L, Whiteley HE, Yiamouyiannis CA,
Schramm CM, Muhammadu F, Thrall RS. 2001. Murine
cytomegalovirus infection alters Th1/Th2 cytokine
expression, decreases airway eosinophilia, and enhances
mucus production in allergic airway disease. J Immunol
167:2798-2807.
Schramm CM, Puddington L, Wu C, Guernsey L,
Ghraee-Kernani M, Phan SH, Thrall RS. 2004. Chronic
inhaled ovalbumin exposure induces antigen-dependent but
not antigen-specific inhalational tolerance in a murine
model of allergic airway disease. Am J Pathol
164:295-304.
Secor Jr. ER, Blumberg JH, Markow MJ, MacKenzie J,
Thrall RS. 2004. Implementation of outcome measures in a
complementary and alternative medicine clinic: evidence
of decreased pain and improved quality of life. J Alt
Comp Med 10:506-513.
Cloutier MM, Guernsey L, Wu CA, Thrall RS. 2004.
Electrophysiological properties of the airway epithelium
in the murine, ovalbumin model of allergic airway
disease. Am J Pathol 164:1849-1856.
Secor Jr. ER, Carson IV, WF, Cloutier MM, Guernsey LA,
Schramm CM, Wu CA, Thrall RS. 2005. Bromelain exerts
anti-inflammatory effects in an ovalbumin-induced murine
model of allergic airway disease. Cell Immunol
237:68-75.
Schramm CM, Guernsey L, Secor E, Thrall RS. 2006.
Tolerance induced by chronic inhaled antigen in a murine
asthma model is not mediated by endotoxin. Biochem
Biophys Acta 1762:499-501.
Kabbur PM, Carson IV, WF, Guernsey LA, Secor Jr. ER,
Thrall RS, Schramm CM. 2006. Interleukin-10 does not
mediate inhalational tolerance in a chronic model of
ovalbumin-induced allergic airway disease. Cell Immunol
239:67-74.
Stoilov I, Krueger W, Mankowski D, Guernsey L, Kaur A,
Glynn J, Thrall RS. 2006. The cytochromes P450 (CYP)
response to allergic inflammation of the lung. Arch
Biochem Biophys 456:30-38.
Matson AP, Zhu L, Lingenheld EG, Schramm CM, Clark RB,
Selander DM, Thrall RS, Breen E, Puddington L. 2007.
Maternal transmission of resistance to development of
allergic airway disease. J Immunol 179:1282-1291.
Secor Jr. ER, Carson IV, WF, Singh A, Pensa M, Guernsey
LA, Schramm CM, Thrall RS. 2007. Oral bromelain
attenuates inflammation in an ovalbumin-induced murine
model of asthma: eCAM online-link:
http://ecam.oxfordjournals.org/cgi/content/abstract/nel110v1
Carson IV, WF, Guernsey LA, Singh A, Schramm CM, Thrall
RS. 2008. Local increases in regulatory T cells
correlate with the resolution of inflammation in murine
asthma. Int Arch Allergy Immunol 145:231-243.
Wu CA, Peluso JJ, Shanley JD, Puddington L. Thrall RS.
2008. Murine cytomegalovirus influences foxj1
expression, ciliogenesis, and mucus plugging in mice
with allergic airway disease. Am J Pathol (In Press).
Singh A, Carson IV, WF, Secor Jr. ER, Guernsey LA,
Flavell RA, Clark RB, Thrall RS, Schramm CM. 2008.
Regulatory Role of B cells in a Murine Model of Allergic
Airway Disease. J Immunol (Accepted pending revisions).
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Research Projects
Active Research Projects
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1 RO1-AI-43573-05 (Thrall) |
Role: Principal Investigator |
July 2004 - June 2009
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National Institutes of Health/Allergy and Immunology
Role of Regulatory T-Cells in a Mouse Model of Asthma
The goal is to investigate the role of regulatory T-cells in the
development of allergic airway disease in a mouse model of asthma.
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1H46MC04457-03 (Thrall) |
Role: Principal Investigator |
July 2008 - May 2008
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Health Research and Services Administration
- Maternal and Child Health Bureau
CT Sickle Cell Newborn Screening Program: Community Based Initiative
The goal is to increase awareness and education in Connecticut regarding sickle cell disease
and trait through community outreach programs and educational offerings.
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(Thrall) |
Role: Principal Investigator |
December 2006 - July 2008
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State of Connecticut Department
of Public Health, Sickle Cell Disease Initiative
CT Sickle Cell Consortium: Lifespan Approach
The goal is to establish a continuum of care including a medical home and
transitional care for individuals with sickle cell disease in Connecticut.
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(Thrall) |
Role: Principal Investigator |
October 2006 - December 2007
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Vaccinex Inc.
Therapeutic Values of Glycosylceramides in Asthma
The goal is to determine if NKT cell agonists modulate the development of asthma. |
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(Thrall) |
Role: Co-Investigator |
July 2006 - June 2008
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Patrick & Catherine Weldon Donaghue Medical Research Foundation
Effects of Omega-3 Fatty Acids on Bone and Frailty
The goal is to investigate omega-3 fatty acid supplementation in osteoporosis. |
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1RO1-AI 56172-01 (Lefrancois) |
Role: Co-Investigator |
September 2003 - February 2008
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National Institutes of Health/Allergy and Immunology
Modulation of Biodefense Responses to Bacterial Pathogens, Mechanisms of SEB Induced Immunity – Project 3
The major goals of this project are to test staphylococcal enterotoxin B (SEB)
activation of dendritic cells (DCs) as a modulator of toll-like receptor (TLR) in lung injury.
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Completed Research Projects
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(Votto) |
Role: Project Coordinator |
October 2004 - June 2007
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Cellular Sciences, Inc.
Inhaled Sodium Pyruvate for the Treatment of Bronchial Asthma
The goal was to determine if the inhalation of sodium pyruvate alters
nitric oxide levels in expired breath of individuals with lung disease.
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1F32-AT001569-01 (Secor) |
Role: Sponsor/Mentor |
February 2004 - February 2007
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National Institutes of Health/National
Center for Complementary and Alternative Medicine
Anti-Inflammatory Effects of Bromelain
This was a training grant for Dr. Secor to investigate if the natural compound
bromelain can alter the development of ovalbumin-induced allergic airway disease
in mice.
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1RO1-HL 68692-03 (Wu) |
Role: Co-Investigator |
July 2002 - June 2007
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National Institutes of Health/National Heart, Lung, and Blood Institute
Murine Cytomegalovirus Modulates Allergic Airway Disease
The goal was to investigate the effect of concomitant CMV infection
on a murine model of asthma.
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Contact Information
Roger Steven Thrall, Ph.D.
Professor of Medicine University of Connecticut Health Center
263 Farmington Avenue
Farmington, CT 06030
Phone: 860-679-4118
Fax: 860-679-1868
Email: thrall@nso2.uchc.edu Helpful Links
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